Grey’s Anatomy: 10 Best Quotes From Season 1 –

Fans got to meet Meredith Grey and the rest of the gang for the first time when Grey’s Anatomy season 1 premiered in 2005. Producing storylines, such as Cristina’s surprise pregnancy, Izzie’s modeling, and the beginnings of Derek and Meredith’s love life, the constant flux of emotions from heartwarming to heart-wrenching (and everything in between) brought viewers back year after year.

Season 1 was brimmed with iconic quotes that set up who each character was as a person. However, it also revealed the private struggles that they may meet in future seasons. Through heartfelt storytelling and memorable quotes, Grey’s Anatomy endeared fans everywhere – to the point that they are still watching almost two decades later.

“Rule Number One: Don’t Bother Sucking Up. I Already Hate You. That’s Not Gonna Change”

Bailey looking serious at the hospital in season 1 of Grey's Anatomy

It is the interns’ first day on the job, and all they need is a little encouragement. Well, they aren’t going to get that from Dr. Bailey. She lays down the law in no uncertain terms with five rules that include the assurance that she is always going to hate them, so they might as well not bother trying to win her over. So much for a relaxed first day.

“I Could Quit, But Here’s The Thing. I Love Playing The Field”

Meredith smiling season 1

Meredith Grey is a fighter and she didn’t go to medical school to give up when the going gets tough. Despite her doubts, she muses on her life choices that have led her to this moment and knows that this is what she wants to do. There are countless other options for careers. There are other games to play, but this is her game, and she is committed to seeing it through to the end.

“Who Here Feels Like They Have No Idea What They’re Doing?”

grey's anatomy the interns all putting their hands up

Meredith needs roommates, Cristina nearly plows into George on her motorcycle, and Dr. Bailey doesn’t seem any more cheerful than their first day on the job. Saying that the interns are exhausted and overwhelmed is an understatement.

Finally, George says what everyone else is thinking. The group raises their hands, all except for Alex, but he isn’t fooling anybody.

“Intimacy Is A Four Syllable Word For ‘Here Is My Heart And Soul. Please Grind Them Into Hamburger And Enjoy”

meredith and derek kissing in elevator

Meredith Grey’s voiceovers are a fountain of great quotes that range anywhere from inspiring to just plain funny. While Mer doesn’t have a problem with the physical side of things, she struggles with emotional intimacy, whether it is with her new roommates, or with her budding relationship with Dr. McDreamy.

“You Want To Call Me Dr. Model? That’s Fine […] While You’re Still Sitting On 200 Grand Of Student Loans, I’m Out Of Debt”

Alex Karev holding a picture of Izzie in Grey's Anatomy

By the time Alex left Grey-Sloan, he was a highly respected surgeon. However, this was completely different from the guy fans saw in season 1, who was an arrogant jerk and was willing to humiliate others for his own amusement. One of the worst examples of this is when he prints out dozens of modeling photos of a lingerie-clad Izzie Stevens and pastes them in the locker room for everyone to see.

Izzie has the last word when she boldly strips down to her underwear and tells him to go ahead and laugh because she is debt-free and he isn’t.

“You’re Just Going To Repress Everything In Some Deep, Dark, Twisted Place Until One Day You Snap And Kill Them?”

Meredith and Cristina arriving at the hospital together with coffees.

There’s a reason that Cristina and Meredith are friends, and their sense of humor is only one of them. Meredith invites George and Izzie to be her roommates, but it doesn’t take her long to realize that being around other people at home is just not working for her. Cristina is seen to be the only one who can truly spot Meredith’s frustration, which further cements their bond.

“Anyone Who Says You Can Sleep When You Die, Tell Them To Come Talk To Me After A Few Months As An Intern”

bailey talks to the interns

Anyone who has had a high-stress job that keeps long hours can relate to this one. It’s not only the job that keeps them from getting enough sleep. There are accidental pregnancies, drunk anesthesiologists, and relationship woes stacked on top of the fact that they have people’s lives in their hands. These interns definitely need more hours in the day to get some much-needed shuteye.

“Why Do I Keep Hitting Myself With A Hammer? Because It Feels So Good When I Stop.”

Meredith Grey (Ellen Pompeo) and Derek Shepherd (Patrick Dempsey) in "Grey's Anatomy."

This is where Meredith’s self-destructive tendencies and her drive to push herself to the brink really come clear. Is she becoming a surgeon because she truly wants to help people, or is she simply hitting that internal self-destruct button just to feel something?

Having a famous doctor for a mother isn’t easy, and apparently comes with a lot of deep-rooted self-worth issues.

“The Problem With Secrets Is Even When You Think You’re In Control, You’re Not”

Meredith Grey on Grey's Anatomy

Another gem of wisdom from Dr. Meredith Grey. Whether in medicine or in personal lives, lies, and secrets both have a way of exposing themselves at exactly the worst time imaginable. Secrets can be toxic, and her life is full of them, especially when it comes to an affair with a certain handsome doctor.

“And You Must Be The Woman Who Is Scr*wing My Husband”

Meredith meeting Addison with Derek in season 1 of Grey's Anatomy

One of the most shocking twists of the season is the introduction to Dr. Addison Shepherd. McDreamy conveniently “forgot” to tell Meredith that he is married, so when Addison shows up to Seattle Grace after weeks of trying to get a hold of her absent husband, it’s a surprise to everyone. Still, there is something satisfying about her casual yet biting quip as she introduces herself to Meredith.